i went to springfield mo and back to northeast pa and the only advice i can give other than what was already given is have a good trip!
wheel bearing check at every rest stop/fuel stop is good,check the tires also,check the springs while you are there to be sure none are broken.check the bunks,and mounts also.check the winch strap,safety chain on the bow also,if equipted.if with the cover,keep an eye on the mirrors for it coming loose.spare bulbs,wire,and connectors if needed.keep the tires inflated to max pressure on the tires.if using the boat for storage arrange the load so it doesnt put too much weight on the toungue or the tires.check the transom saver.
also,it sounds stupid,but disconnect the batteries,due to if you have a short in the wiring it doesnt ruin your trip down/back.a small inconvience there and back,but if anything comes on like a bilge pump/aerator pump,it doesnt burn it up.
have a good trip!