Chris,
This is just part of one hit I got when I did a search on Rimadyl.
It's a non-steroid anti-inflammatory drug(NSAID).
The action of these drugs is similar to aspirin, in that they inhibit inflammatory substances called prostaglandins (PGEs), which cause pain, inflammation, and fever. These drugs are safer than aspirin.
There is risk of liver failure with all NSAIDs. Liver necrosis in Labrador Retrievers caused by Rimadyl have been reported in the largest numbers. The manufacturer of Rimadyl alleges these reactions are attributed to the fact that Labs are the most common breed, and Rimadyl was the first and most commonly prescribed NSAID. Rimadyl may be getting a bad rap. All NSAIDs have the potential to cause liver failure. Blood tests before administration of NSAIDs cannot predict this liver reaction. The risk of this reaction is small (1:10,000 with Rimadyl). NSAIDs are relatively new to veterinary medicine. Veterinarians have little clinical experience with these drugs. Although every manufacturer has data that alleges their drug is safer than the others, no credible non-manufacturer-sponsored data exists which accurately compares these drugs.
Because of the Labrador Retriever statement I want you to see this asap.
NSAIDs Dos and Don'ts
Do Ask your Vet for a written warning about side effects, and read this warning. Ask to see the manufacturer's package insert.
Do Test your pet for kidney problems before starting NSAIDs. This is especially important in older pets, who are prone to kidney failure. A urinalysis and blood test (BUN, Creatinine) are essential.
Do Monitor kidney and liver function if your pet is on these drugs for a prolonged period of time. Monitoring is recommended whenever the dosage is increased.
Do Give Zantac or other antacid medication daily to prevent duodenal ulcers, a common side effect of all NSAIDs. Unfortunately this will not prevent gastric ulcers.
Do Give polysulfated glucosamines (PSGAs -- Adequan, Glycoflex, or Cosequin) with prolonged use of NSAIDs for arthritis and degenerative joint disease. NSAIDs relieve pain, but unfortunately over a long period of time NSAIDs can contribute to cartilage degeneration. PSGAs help cartilage to heal. NSAIDs can cause G.I. ulceration. PSGAs are part of the protectant lining of the G.I. tract. NSAIDs are better tolerated with PSGAs. PSGAs also protect the kidney.
Do Stop the medication at the first signs of gastric upset, nausea, lack of appetite, vomiting or diarrhea.
Don'ts
Do not mix NSAIDs.
Do not give NSAIDs with steroids like dexamethazone, prednisolone, Vetalog or Depomedrol. Gastrointestinal ulceration and bleeding can result. A 3-to-5 day withdrawal period is necessary if you switch from one drug to another.
Do not give NSAIDs in patients with known impaired gastrointestinal, kidney, cardiovascular, or coagulation functions. If liver enzymes are elevated, use only at a lowered dose, and with liver treatment medication (i.e., SAM - E)
Do not give NSAIDs with Enalapril or other ACE inhibitors, Lasix, or with nephrotoxic drugs like aminoglycoside antibiotics or psychotropic drugs (Prozac, Clomiclam).
Do not give NSAIDs in dogs with Cushing's disease or other diseases where the patient is predisposed to thromboembolisms (blood clots).
Do not use NSAIDs in trauma patients or critical care patients due to potential clotting problems and nephrotoxicity.
A final note:
Relief from pain by NSAIDs is an individual response. If your pet does not get adequate relief from pain and return to normal function with one NSAID, it is worth trying a different NSAID.
I hope this helps Chris and good luck,,
Bill